Increased pulmonary responses to acute ozone exposure in obese db/db mice
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منابع مشابه
Increased pulmonary responses to acute ozone exposure in obese db/db mice.
Epidemiological studies indicate the incidence of asthma is increased in obese and overweight humans. Responses to ozone (O(3)), an asthma trigger, are increased in obese (ob/ob) mice lacking the satiety hormone leptin. The long form of leptin receptor (Ob-R(b)) is required for satiety; mice lacking this receptor (db/db mice) are also substantially obese. Here, wild-type (WT) and db/db mice wer...
متن کاملAugmented Pulmonary Responses to Acute Ozone Exposure in Obese Mice: Roles of TNFR2 and IL-13
BACKGROUND Acute ozone (O(3)) exposure results in greater inflammation and airway hyperresponsiveness (AHR) in obese versus lean mice. OBJECTIVES We examined the hypothesis that these augmented responses to O(3) are the result of greater signaling through tumor necrosis factor receptor 2 (TNFR2) and/or interleukin (IL)-13. METHODS We exposed lean wild-type (WT) and TNFR2-deficient (TNFR2(-/...
متن کاملtranslational physiology Responses to ozone are increased in obese mice
Shore, S. A., Y. M. Rivera-Sanchez, I. N. Schwartzman, and R. A. Johnston. Responses to ozone are increased in obese mice. J Appl Physiol 95: 938–945, 2003. First published June 6, 2003; 10.1152/japplphysiol.00336.2003.—Epidemiological data indicate an increased incidence of asthma in overweight adults and children. Ozone (O3) is a common trigger for asthma. Accordingly, the purpose of this stu...
متن کاملResponses to ozone are increased in obese mice.
Epidemiological data indicate an increased incidence of asthma in overweight adults and children. Ozone (O3) is a common trigger for asthma. Accordingly, the purpose of this study was to compare O3-induced airway hyperresponsiveness and airway inflammation in lean, wild-type (C57BL/6J) mice and mice that are obese as a consequence of a genetic defect in the gene encoding the satiety hormone lep...
متن کاملPulmonary responses to subacute ozone exposure in obese vs. lean mice.
The purpose of this study was to determine whether obesity affects pulmonary responses following a 3-day ozone exposure. Obese db/db and lean wild-type mice were exposed to ozone (0.3 ppm) for 72 h. In wild-type mice, ozone exposure caused pulmonary injury and inflammation, and these events were associated with reduced pulmonary compliance. In db/db mice, ozone-induced neutrophil recruitment to...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Lung Cellular and Molecular Physiology
سال: 2006
ISSN: 1040-0605,1522-1504
DOI: 10.1152/ajplung.00386.2005